conclusions using the pcr-rflp method, three distinctive h. pylori caga genotypes were detected in antral biopsies. genotype i, which was predominant among the isolates, was significantly associated with gastritis. however, the data showed that caga genotype iii may play a role in duodenitis and duodenal ulcers in patients infected with h. pylori. patients and methods a total of 161 gastric bio...

objective(s):leptin receptor (lepr) is a member of the class i cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. we have investigated the effect of q223r polymorphism on the breast cancer susceptibly in a sample of iranian subjects. materials and methods:we utilized a polymerase chain reaction (pcr) restriction fragment length polymorphi...

background interleukin-16 (il-16) is an immunomodulatory cytokine, which plays an important role in some inflammatory and autoimmune diseases such as hepatitis b, which is a major health concern worldwide. objectives in this study, we aimed to investigate the plausible association between il-16 polymorphism and chronic hbv susceptibility in an iranian population. conclusions these findings show...

Methods Ninety seven JIA patients with a polyarticular course were enrolled into the study. All patients received methotrexate treatment for at least for 6 months. The efficacy of treatment was judged by improvement in physician’s global assesment, the number of affected joints, erythrocyte sedimentation rate and C-reactive protein. RFC and ATIC gene polymorphisms were determined by polymerase ...

Background: Follicle stimulating hormone (FSH) receptor plays an important role in FSH signaling during reproductive development. Any changes in FSHR gene is resulted in alteration of amino acid in protein chain, consequence to affect the binding affinity, intracellular signaling and expression levels of FSHR. FSHR polymorphisms can be involved in etiology of many reproductive disorders such as...

ackground: knowing the human platelet antigens (hpa) and genes frequency in different populations is important not only for population studies but also for clinical transfusion practice. hpa genes frequency in iran is not evaluated, so we investigated the hpa-2, hpa-3, and hpa-5 frequency and their polymorphism. materials and methods: dna from 120 iranians (99 iranian blood donors and 21 patien...

conclusions the results of antifungal susceptibility tests demonstrated that voriconazole was the most active drug against candida isolates. candida albicans is the most common yeast isolated from human blood world-wide; the unexpectedly higher rate of c. parapsilosis isolated in this study necessitates more studies with larger sample sizes in iran. results candida parapsilosis (c. parapsilosis...

background: sulfatase 1 ( sulf1 ) function is to remove the 6-o-sulphate group from heparan sulfate. this action changes the binding sites of extracellular growth factors. sulf1 expression has been reported to be changed in angiogenesis. we hypothesized that single nucleotide polymorphisms (snps) of sulf1 would impact clinicopathologic characteristics. objective: study of sulf1 gene polymorphis...